Thanks for your perspective. As I've said before, I lean towards the gender is biological (neurological) side. It could be because of my own experiences (gender dysphoria since before 3 years old) or my academic background (both undergrad and postgrad education in the medical sciences). My honest assessment is that gender is mostly determined by biological factors.

However, I am very interested in the ongoing debate, and I will remain open-minded to any views or new evidence that might come up. In fact, I am writing a new article on finding common ground with those sympathetic to Butler's views on gender, and it is coming out in the next month.

I am very aware of neuroplasticity. However, I have seen no evidence that it affects gender. Based on my understanding of evolution, I also don't think that neuroplasticity would affect the 'core' part of gender, including the fundamental sense of gender identity. I can't rule out its possible effects on some gender related behaviors though.